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Metabolism Alprazolam is extensively metabolized in people, mainly by cytochrome P450 3A4 (CYP3A4), to two significant active metabolites inside the plasma: 4-hydroxyalprazolam and α-hydroxyalprazolam. The plasma circulation levels of the two Lively metabolites are under 4% on the guardian. The described relative potencies in benzodiazepine recept